When you retarget animation from one character to another, a new layer containing the retargeted animation is automatically added to the Animation Layer Editor. This layer is named RetargetLayer by default. You can adjust animation on the RetargetLayer, or add additional layers to organize your work. See also What are animation layers?
To key on top of retargeted animation
Ensure that the Reach values of any effector you want to adjust are set to 1. Otherwise, moving or rotating the effector will have no effect. Reach is set to 1 by default for the ankle effectors.
The target character animation is now modified, and all of its animation is contained on the selected animation layer. You can create more layers to organize your adjustments, or continue using the single layer. When you finish making adjustments, you can merge animation layers together, or bake the animation to the target character.