The Hybrid configuration is intended for use when creating debug builds of your plug-in. When you've finished development and want to create your DLL for distribution change this to Release and rebuild.

The Debug configuration requires a debug build of 3ds Max with symbols included. These builds are available to Autodesk Developer Network members. For more information see the topics Support for Developers and Debug Builds of 3ds Max. Do not use the Debug configuration unless you have a debug build of 3ds Max, otherwise 3ds Max will become unstable.

Use the Release configuration when you wish to create a production ready build.