Most menu buttons and operations have a hotkey equivalent. Smoke employs a robust hotkeys arrangement, including a Hotkey Editor that allows you to customize existing hotkeys and create new ones. See Managing Hotkeys.
The Ctrl and Alt keys on the right side of the keyboard are used for marking in and out points, respectively. The left Ctrl and Alt keys are used for all other hotkey combinations.
The right arrow and left arrow hotkeys allow you to navigate through clips in the Source Area, Record Area, and players. In the Source Area, you can navigate through clips using these hotkeys even when you are selecting clips with the arrow cursor. See The Cursors.