There are two types of hotkeys: map-to-button and functional hotkeys.
Map-to-button hotkeys are keystroke sequences that are mapped to a button or a field on the current menu. You can create and edit as many map-to-button hotkeys as you like. You can even assign a hotkey to options in a pop-up menu.
Functional hotkeys are predefined hotkeys for specific functions. You cannot create new functional hotkeys, but you can redefine and remap the ones provided with the system.